ISA-95 was developed with the purpose of integrating Enterprise and Control systems. Enterprises use this standard to prepare and realize integration projects. It is less well known that the ISA models and terminology can also be used to analyze manufacturing companies. The Ordina ISA-95 & MES competence centre developed an approach for the analysis of the AS-IS and the TO-BE situation, based on ISA-95. This approach has been applied for several clients (e.g. Johnson & Johnson, AKZO Nobel, Philips, Abbott laboratories) with different objectives. E.g. one end user client needed to list the current automation systems and platforms and compare the situation of several sites. Another had to develop a URS for an enterprise wide tracking and tracing system (so comparison of the requirements of several plants was needed). A third company aimed at developing an MES automation strategy for the coming five years; here the ISA-95 models where used as a basis for an interview program. The ISA-95 analysis approach is suitable in all these and more-situations.